A seemingly routine murder investigation by the LAPD Robbery-Homicide Division is interrupted by the arrival of Deputy Chief Brenda Johnson, the new head of the LAPD’s Priority Murder Squad. An outsider from Atlanta in her first week of service, Brenda has already begun to face the resistance of long-time high-ranking officers and only her assistant, Sgt. Gabriel, seems willing to try to work with her.

Brenda and the team must investigate the murder of high-profile model Heather Kingsley, who dies as a result of nicotine poisoning. As Brenda investigates, she is drawn into the world of celebrity beauty, where illusion is everything, and the standard high.

Brenda enters the high-stakes world of pharmaceutical research, when a drug trial for new anti-addiction medication lead to the death of one of the principal investigators. Nothing is quite as it seems as she investigates the high-powered president of the drug company sponsoring the trial, the seemingly easy-going psychiatrist and the teenaged participants in the study.

When a gay man is murdered, seemingly the latest victim of a string of hate crimes, Brenda must confront prejudices inside and out of the LAPD. Meanwhile, Flynn and Taylor step up their efforts to undermine Brenda once again, but with unexpected effects, as the team begins to rally around Brenda.

Things are not as they seem when Brenda and the team investigate the accidental murders of three college students caught in the middle of a gang shootout. Brenda must also continue her attempts at keeping her relationship with Fritz under wraps while her mother remains in town.

Brenda finds herself involved in a cover-up of her own when she helps the PHD investigate a non-priority case. Why? Because the deceased woman was found in Provenza's garage...Once again, the team finds themselves racing against the clock before the LAPD brass discovers what they're up to. Will Brenda be able to protect her team and their hard-earned trust?

When the drowned bodies of a mother and daughter are found by fishermen, Brenda and the team must determine if the apparent suicides are more than that. Following a strange coil of discoveries, the most surprising revelation that surfaces is one about the killer.