A seemingly routine murder investigation by the LAPD Robbery-Homicide Division is interrupted by the arrival of Deputy Chief Brenda Johnson, the new head of the LAPD’s Priority Murder Squad. An outsider from Atlanta in her first week of service, Brenda has already begun to face the resistance of long-time high-ranking officers and only her assistant, Sgt. Gabriel, seems willing to try to work with her.

Brenda and the team must investigate the murder of high-profile model Heather Kingsley, who dies as a result of nicotine poisoning. As Brenda investigates, she is drawn into the world of celebrity beauty, where illusion is everything, and the standard high.

Brenda and the Priority Homicide Team investigate a sniper who is killing gang members in and around MacArthur Park. Offering assistance is an ex-Army colonel who believes the sniper to be his son. As an all-out gang war looms, Brenda tentatively accepts his assistance.

The murder of an adolescent girl from Mexico, found dead in the Los Angeles River, proves difficult and painful for Brenda and her team. At first, a known sex-offender seems the likely candidate, but questions arise about why the girl and her mother were brought to the US, leading the investigation in another direction.

An unnamed source files a grievance against Brenda in the midst of a high-profile investigation of a murdered L.A. filmmaker. With her career on the line, Brenda is skeptical of Chief Pope's intentions when he volunteers to help. In classic Brenda style, she spurns the accusation and the PHD team comes together to act in unison, sending shock waves through the entire department.

Brenda and her team race against the clock to get to the truth, as things don't add up when an LA cop turns up dead. Meanwhile tension increases between the Priority Homicide Division and the Robbery-Homicide Division.

Brenda and the team find themselves wading through a long list of suspects when a celebrity photographer takes a fatal fall from his hotel room balcony. In the meantime, Brenda starts to feel like Fritz is behaving strangely, making her realize that superstars may not be the only ones who have secrets to keep.

Brenda and Fritz have a hard time agreeing who is in charge when an informant's wife and and FBI agent are both murdered. When the killer's identity is uncovered, the PHD finds themselves under attack.

Brenda and the team investigate the grisly slaying of a family, and the only survivor is the drug-addled teen son. Meanwhile, a financial crisis rocks the LAPD, bringing about budget cuts and possibly Provenza’s early retirement. Meanwhile, Fritz hopes to move into a new house with Brenda.

A recently released sex offender is accused of kidnapping a child, and with time running out, Det. Gabriel makes a startling choice.

Still experiencing the strain of her case, Brenda finds herself under another time crunch when she must disprove a questionable alibi within 48 hours to prevent the investigation from falling flat. As Brenda searches for the truth in her case, she discovers some inside information that may have an unfortunate effect on her relationship with Fritz.

When a massive fire breaks out in Griffith Park, Priority Homicide is on hand to help. Meanwhile, Brenda and Fritz are living in a small apartment and getting on each other's nerves.

The newly renamed Major Crimes Division investigates the death of a teenager that may be related to a planned massacre.

While investigating the homicide of an entire family, the team once again finds themselves entangled in an FBI case. They also find themselves distracted by an unusually surly Provenza.

The team digs through several suspects that surface after a man's body is found inside an oversized box. Brenda finds the case the perfect platform to play the role of teacher to Gabriel as he prepares for his detective exam. When Brenda's niece, Charlie, gets out of hand, she and Fritz must consider ending her summer vacation with them.

While investigating a suspicious suicide, the squad wades into a nasty child-custody dispute between a dying man and his meth-addicted ex-wife. Meanwhile, Pope applies for the police chief job, but Brenda might have something to say about whether or not he gets it.

After a parole board member is viciously murdered during a panicked phone call with Sgt. Gabriel, Pope announces an overreaching plan to boost the police department’s image. His plan, however, hinges on Brenda first being able to solve the crime.

The murder of two paramedics leads the LAPD and the FBI on separate investigations on a case that could be the precursor to a major terrorist attack. But Brenda fights to remain a step ahead, even though she's forced to work with the counter-terrorism unit's Chief Tommy Delk, who happens to be one of Brenda's fellow finalists for the job of Chief of Police.

The squad investigates the death of a deputy sheriff; the judge considers dropping the charges against Brenda.

Brenda finds a young couple involved to in the investigation by accident after finding two people dead outside in the street Brenda has no idea that the DA is watching her every move Capitan Raydor and Chief Pope find out who the leak is.

In the series finale, we bid a final farewell to Brenda Leigh Johnson. When a young man calls 911 to report seeing someone being buried in Griffith Park, police find not only her remains, but those of several other women who were kills as far back as two years ago. Brenda immediately suspects Philip Stroh and, despite departmental restrictions, sets out to finally tie him to the murders. Meanwhile, the witness who called 911 makes Brenda look at her life and future.

Stay tuned to the next show, Major Crimes, which will pick up from the moment The Closer ends. A large portion of the characters are moving to the new show. to work under the new supervisor of Major Crimes, Captain Sharon Raydor.