A mysterious alien object attacks a Naval ship and crew. Dr. Molly Anne Caffrey, a government contingency analyst, is contacted by the Deputy National Security Advisor, J.T. Baylock, to investigate the incident along with a special scientific team of her choice.

Molly and Baylock realize the Threshold detainees must be moved immediately to a more secure facility in West Virginia when a prisoner attacks and infects a security guard, then tries to break himself and other infected prisoners out of their cells.