Peter's boss Angela sends him back to the third grade so that he can qualify for a work promotion. Meanwhile, Brian, Frank Sinatra Jr. and Stewie open the coolest club in Quahog.

After Lois dominates her competition in the boxing ring, Peter decides to become her promoter.

When Mayor West marries Lois’ sister, Carol, they move into the Griffin’s house to be one big “happy” family. To make room for everyone, Stewie is bumped out of his room and takes over Chris’ room, but not everyone is annoyed by the change. Peter and Mayor West bond and become best friends.

When Peter decides to become a famous actor, he becomes Tom Tucker's agent as his first step toward stardom. Meanwhile, Chris dates a girl who looks disturbingly like a member of the Griffin household.

To boost Chris' self-esteem, Peter and Lois send him to space camp. When camp ends and the Griffins come to pick Chris up, they accidentally are launched into outer space, and it's up to Chris to land the clan safely back on earth.

Stewie and Brian travel back in time to 17th-century Jamestown and make too many close calls with changing history. Stewie decides to destroy his time machine, but comes to regret it when Brian dies after being hit by a car. Devastated by his death, the Griffin family goes out and adopts another dog from the pet store, Vinnie, who is quickly accepted by all the members of the Griffin family, other than Stewie, who can't get over the loss of Brian.

To help Chris ace his ninth grade history class, Stewie and Brian employ the time travel machine for educational purposes. Not surprisingly, all three get stuck in the past.

Quagmire lands free plane tickets for the guys' trip to San Francisco, but they begin to doubt his flying abilities after getting a look at the auto-pilot function. While in the air, sudden events give Quagmire's skills a run for the money.

Lois receives a surprising birthday present from her father, Carter Pewterschmidt, that leads to an unfortunate accident leaving him dependent on Lois and the Griffin's care.

Peter gets himself arrested to avoid Lois' special Thanksgiving dinner; A secret that Stewie's been keeping from everyone is revealed.

When Joe asks Peter to be the godfather to his daughter, Peter commits to his mistaken interpretation of the role so much that he becomes a real gangster.

Brian's new job as a journalist leads him to uncover that Pawtucket Pat, Quahog's hero and brewery founder, took part in racist actions against Native Americans. The town becomes divided on whether or not to remove the statue that commemorates him.

The guys' physical prowess is tested at Mayor West's dude ranch. Meanwhile, Stewie thinks he's gotten his first period.

Lois decides to sell the family's television to help pay for Christmas presents, but when Kevin James gets upset over losing Peter as a viewer, he apparates into the Griffin house.

Brian becomes romantically interested in someone and it inspires him to use Stewie's time machine. Strange consequences result from their journey.

When Quagmire starts dating a mystery woman, Peter, Joe and Cleveland go on a stakeout and discover her to be the librarian.