A car crash at a funeral brings a bickering family into the hospital. Back from New York, Arizona ends up caught between Alex and Andrew. While Ben takes on a new parenting role, Amelia helps Meredith and Maggie through a problem.

A young boy is admitted to Grey Sloan Memorial and his case has a profound impact on the doctors. Meanwhile, April is faced with a surprising patient, and Jo continues to deal with her estranged husband.

The stress of managing the hospital and coming to terms with Ben’s decision to become a Seattle firefighter pushes Bailey to her limits.

Meredith has a patient whose family is celebrating Day of the Dead, making the doctors remember loved ones they have lost. Richard shares unexpected news with Meredith about her father, Thatcher. Meanwhile, Teddy tries to tell Owen that she is pregnant but they get sidetracked, and Jo encourages Link to pursue one of the doctors.

When a trauma patient arrives at Grey Sloan, it forces Jo to confront her past. Meanwhile, Bailey and Ben have to talk to Tuck about dating.

Meredith and Carina question DeLuca’s uncharacteristic behavior when he volunteers to perform a life-threatening task during a blizzard. Meanwhile, Bailey tries to help Joey with his future, while Richard trains a new intern at the hospital.

Bailey and Ben face a huge, life-altering decision, while Meredith and several of the doctors reflect on the past.

The doctors of Grey Sloan Memorial must contend with the COVID-19 pandemic; an unintentionally started fire has first responders from Station 19 bringing patients into the hospital for treatment.