As the rest of the doctors prepare for Bailey's wedding, Richard helps her through a bout of pre-wedding jitters. Meanwhile, Lizzie butts heads with Meredith, and Callie and Jackson try to convince Derek to participate in a risky surgery that could fix his hand.

Bailey puts her wedding day on hold and continues her efforts to save Adele's life, Cristina and Owen remain undecided about their pending divorce, while Arizona and Callie try to get their spark back. Meanwhile, the hospital becomes inundated with a group of bikers after a horrible accident.