Detective and family man John Lowe investigates a chain of gruesome murders in Los Angeles. A mysterious tip points him to the enigmatic Hotel Cortez.

Fashion mogul Will Drake brings couture to the Hotel Cortez. A model catches The Countess's eye. John learns about the hotel's sadistic first owner.

John receives an invitation to attend an exclusive Devil's Night Soiree. Alex tries to diagnose Holden's strange condition.

Alex uses an unconventional treatment to save a dying patient. A Halloween-hating couple tests Iris’s limits.

Ramona and Donovan enact their plan for revenge. Liz Taylor finds true love. The resident of Room 33 is revealed.