Dr. Arcane attempts once again to obtain the bio-restorative formula from the Swamp Thing. However, this time Arcane has a helper, and the Swamp Thing knows her as his late wife, Linda Holland.

Arcane has unleashed his latest mutant monster into the swamp to eat everything it sees and if this test trial works, then more will be released. To ensure that the Swamp Thing does not interfere, he takes a hostage and bargains for immunity.

Still fruitlessly searching for her missing son Jim, Tressa is diverted when she hears the voice of her former boyfriend, a radio jockey from the 70's. Tressa begins a second hunt for answers, as she discovers what really happened when her boyfriend disappeared 18 years ago, guided by his voice from the grave.

The Swamp Thing's worst enemy is also the enemy of the swamp...himself.

When Arcane unleashes a genetic assassin into the swamp in the form of a virus, he gets more than he bargained for; he not only gets rid of the Swamp Thing, but he accidentally brings Alec Holland back.

Arcane finally resurrects his wife Tatania, only to learn the woman is an impostor. A few hours in the lab with this woman leads Arcane to discover the true whereabouts of his beloved wife and the identity of her captor; General Sunderland.

The Swamp Thing gets addicted to hallucinogenic iguana eggs which makes him live out a fantasy of being human again. His addictions almost cost Will his life when Arcane gets involved.