Fellow scientist and friend Bruce Banner comes to Reed looking for help. But his dark secret is soon revealed - he's the Incredible Hulk! When Banner reverts to his giant green alter-ego and goes on a rampage across New York City, the Fantastic Four must stop him.

Reed's miniaturization experiment malfunctions, shrinking the team and putting them at risk when H.E.R.B.I.E. incorrectly identifies them as vermin and tries to exterminate them.

The Puppet Master gets the city to turn on the Fantastic Four. The Four must clear their good names and stop the Puppet Master from taking over the minds of everyone on Earth.

The Fantastic Four return to New York to find that Doom has taken over the city and due to a change in history, they never got their powers. The Four must go back in time to set things right and to stop Doom.

The Grandmaster forces the Fantastic Four to battle Ronan the Accuser, Impossible Man, Annihilus, and Super Skrull. The fate of humanity depends on the winners of this mighty contest.