As the 4400 become even more disenchanted with their accommodations, new rules have everyone on edge. Andre and LaDonna help Claudette push her newfound ability to new limits. Shanice gets an unexpected visitor.

LaDonna signs up for 15 more minutes of fame but quickly realizes she doesn't have the clout she once had. Jharrell picks an inopportune time to speak his truth, and it may cost him dearly. Andre is eager to get back to medicine.

Keisha hears the truth about the day she lost her sister, moving her to take a chance. Shanice and Andre enjoy a day out. Hayden and Mariah grow closer.

Jharrel and Keisha must earn the trust of the 4400 if they want to help keep them safe. Hayden convinces LaDonna and Andre to visit Ypsi Med and Rev continues to grow his flock.

Logan's adjustment to Shanice's return has been harder than he let on, meanwhile, Rev is beginning to see the light. Mildred lets her emotions get the better of her, possibly endangering the rest of the 4400.

With everyone at the Bois Blanc still on edge, the government deals another blow to the 4400. Meanwhile, Jharrel gets some shocking information about his brother, Shanice and Andre continue to grow closer, and Mildred resurfaces.