Duckman is cast in a hospital educational film with Joe Walsh; for his part he is put into a MRI chamber. The film crew is thrown out of the lab and Duckman forgotten. Left too long in the chamber, a mutation occurs which a doctor identifies as a cure for cancer. Now everyone wants Duckman's brain for their own purposes. Meanwhile, Agnes is still impersonating Grandma-ma.

Bernice travels to Washington to assume her new role as Congresswoman. Duckman spots a woman who happens to look like Beatrice, but gets hit by a bus. It turns out that she is Beatrice and Bernice's long lost triplet. Bev realizes the only way to keep Duckman alive is to pretend to be Beatrice.