Several youths involved in an experiment focusing on mind augmentation receive a remarkable increase in their intelligence. However, when the drug they are taking induces the teens to follow some of their more primitive instincts, they embark on a series of violent and dangerous escapades, and it's up to the M.A.N.T.I.S to save them and their victims.

The MANTIS is left for dead when, Solomon Box, the MANTIS' chief nemesis, uses his political muscle and the authorities perception that the MANTIS is a vigilante, to persuade the police to hunt him down.

The Port Columbia police force, under the direction of Solomon Box, continues it's attempt to hunt down the MANTIS.

Stonebrake's experiment with a DNA hologram turns into a total disaster when an electrical accident causes the hologram of an ancient druid to materialize. Now that he is back, the druid intends to kill the judges and bring back his fame.