Dwayne, Ron, Kim, Freddie and Ernest head to Devil's Island, South Carolina for spring break. Whitley joins them at the last minute after Julian has to cancel their vacation due to a job interview. Ernest has big plans for Freddie, but passes out drunk. Ron tries to put the moves on Kim. A pair of murderous drug dealers searches the gang's van for a missing duffel bag. Dwayne and Ron discover money and drugs in the bag and try to go the police. Freddie and Kim meet the drug dealers on the beach and flirt with them, unaware that they are criminals. Dwayne and Ron return to the house after missing the ferry. Dwayne overhears the men threatening to kill him and tries to make a break for it.

Julian shows up to surprise Whitley, who wants nothing to do with him. Dwayne and Ron dress like women to get past the drug dealers and onto the ferry. They arrive at the police station to discover that they accidentally brought Julian's bag instead of the one with the drugs and cash. Paul and Eric search the house, failing to recognize Dwayne and Ron (who are still disguised as ""Diana"" and ""Rhonda""). They promise to return that night. The gang fears that the police will not make it in time because a storm has cancelled all ferry service. Kim, Freddie, Ron and Mandy head out in search of help. Whitley decides to sleep with Julian, but he doesn't think the timing is right. Dwayne hears the dealers coming and bursts into Whitley and Julian's room. Whitley gets into an argument with Dwayne after telling him that she is a virgin. As she opens the door to get him to leave, she gestures with a candlestick holder and cracks Eric over the head. The trio struggles with the men until Walter and