During her first few days at Hillman College, Denise Huxtable finds herself at odds with her new roommate, Jaleesa, a 26-year-old freshman with a mysterious past.

The girls plan Operation Yogi, a plot to steal the rival school's bear-head mascot, but a visit from Denise's grandfather makes a boo-boo inevitable.

In the family tradition of "Combustible" Huxtable, Denise is chosen for Hillman's track team, but after a few practices she starts running out of steam.

Tired of being hit on by men, a grad student decides to turn the tables and seduce Dwayne.

Hillman alumna Lettie Bostic fills in as dorm monitor, but her strongly voiced opinions have the girls considering mutiny.

Clair Huxtable visits Denise bearing motherly advice as well as news that conflicts with Denise's summer plans.

As the school year begins, Dwayne faces the prospect of taking a calculus class from Col. Taylor, a tough professor nicknamed ""Dr. War."" He fears that Col. Taylor could expose his academic success as a fluke and destroy his dreams of becoming an engineer, so he asks Walter to help him get into another section. Walter believes that Dwayne could thrive under Col. Taylor's tutelage, and asks the professor to talk to him. Col. Taylor manages to change Dwayne's mind and convince him to enroll in his class. Whitley meets new roommate Kim Reese, a headstrong freshman who plans to become a doctor. Whitley hopes to intimidate Kim and drive her to another room, but finds it impossible to break her. Jaleesa's cheerful freshman roommate, Freddie Brooks, develops a massive crush on Dwayne.

Kim becomes overwhelmed by her hectic schedule, as she tries to balance pre-med courses with work and extracurricular activities. She also obsesses over her grades, suffering from nightmares about getting too many B's to make it into medical school. She buys a datebook and tries to plan every moment of her day, ignoring her friends' warnings that her lack of sleep could endanger her health. Kim finally agrees to cut back on her activities after fainting in the Pit. Mr. Gaines quarrels with his wife over the presence of their grown son, whom he wants to throw out of the house. Mr. Gaines crashes at Col. Taylor's place after Velma kicks him out, and quickly wears out his welcome.

Dwayne and Whitley run into each other on a flight back to school. Whitley finds that Dwayne has changed over the summer, as he is dressed in an expensive suit and seems to have matured during his successful internship at Kinishewa. Dwayne comforts Whitley when the plane experiences turbulence. Whitley kisses Dwayne in front of her entire dorm, prompting much teasing from her friends. Each insists that they are only friends. Whitley goes to Dwayne's apartment to see him, but is turned off when she finds him dancing like an idiot at a party. The residents of Gilbert Hall struggle to adjust to the fact that the dorm is now coed. Walter is the resident director, with Jaleesa as resident assistant.

Dwayne's old friend Milt comes for a visit. He believes that Hillman is holding Dwayne back, and encourages him to transfer to the University of Pennsylvania. Milt also recommends that Dwayne distance himself from ""dead weight"" like Ron. Dwayne considers his friend's words, until a talk with Whitley helps remind him of Ron's good qualities and the feeling of family that Hillman holds for its students. He defends the school's academic reputation to Milt. Col. Taylor and Mr. Gaines attend a reunion for U.S. servicemen. Col. Taylor tries to start a romance with a nurse he knew in Vietnam, only to discover that she is a complete mess.

Whitley plays matchmaker for Dwayne and a beautiful coed in the hopes of convincing him to move on. However, she becomes extremely jealous and tries to sabotage the couple's date. Dwayne and Whitley try to establish some ground rules in an attempt to save their friendship. Walter angers Jaleesa by claiming that women cannot play poker. He bets that she cannot teach Freddie how to play, while Jaleesa challenges him to turn novice Kobie into an accomplished player. Neither apprentice picks up the game, but Jaleesa literally beats the pants off of Walter.