This pilot launches the saga of the Cannon family as they fight to establish a ranch in the Arizona territory of the 1870s. Marauding Apaches led by Cochise are on the warpath. The Army orders the Cannon family to move on, but Big John Cannon won't budge. While his brother Buck rides off to recruit gun-carrying cowhands, Big John learns of another enemy: a Mexican land baron claims the Cannon property, and dispatches his men to seize the cattle.

Buck, Manolito and Billy Blue are sent to Tucson for food, supplies and boots, but are sidetracked instead by women and song.

While John Cannon awaits his trio's return with the goods, Buck promptly enters a poker game with cowhand Kansas and loses the supply money, Manolito courts Pearlita who rolls him for his money, and Billy Blue sets out with little Rag-Tag Tina to buy the fanciest pair of boots in Tucson.

Problems grow when the boys try to help Fergus MacLeish and his wife from being held up, only to lose the guns they need in Tucson.