Richard Sackler begins to launch a powerful new painkiller, a rural doctor is introduced to the drug, a coal miner plans her future, a DEA Agent learns of blackmarket pills, and federal prosecutors decide to open a case into OxyContin.

OxyContin is on the market but faces a potential threat, Purdue’s vast influence reaches the town of Finch Creek, Bridget steps outside her DEA authority, and the criminal investigation of OxyContin begins.

Doctor Finnix begins to taper Betsy off OxyContin, Bridget sees the toll the drug is taking on communities, Rick and Randy investigate the world of “pain societies”, and with sales climbing, Richard Sackler makes bigger plans for his new drug.

With OxyContin abuse spreading across the country, Bridget brings the fight to Purdue while Rick and Randy seek to find a whistleblower within Purdue to tie their case together.

Rick and Randy’s criminal investigation now threatens Richard Sackler’s empire, activists take action against Purdue, and Finnix tries to heal his beloved community that’s been ravaged by addiction.