Dr. Tenma, Director General of the Science Ministry, loses his son Tobio in an accident. He decides to create the robot Astro Boy, who looks just like Tobio, using the best of the Science Ministry's technology.

It is the year 2000 and robots have been put in charge of making other robots when there are no longer enough people to do the work. Astro Boy dreams of having a real mother, just like human boys. The robot workers are making an experimental new robot named Colosso who goes berserk and escapes shortly after coming to life. The only hope is for Astro Boy to stop him before he cause too much trouble. (In the original Japanese version, Colosso was named "Frankenstein")

Astroboy is selected to lead a search party to find the survivors of the first manned expedition to Mars. This meets strong objection from the spaceship's captain, who protests taking orders from a robot.

Professor Nutty Fruitcake grows giant fruits and vegetables. One day he breeds giant snails thinking they would be harmless, one million snails to be exact. The snails fill the mountain side and overflow into cities.

Astroboy wakes up in the middle of the desert, nearly drained of power and unable to remember how he got there. He is helped by Ali Baba, but in return Astro must battle 'The Sphinx'. This is not a real sphinx, but a robot which guards a desert tomb.

One day, excitable Mr. Pompous was relaxing at home when suddenly a mysterious ship crashed through his front door. Clearly the ship was something from the future.