Espionage, crime and politics collide in modern day Mexico City. A brilliant but self-destructive CIA officer, his young and ambitious Mexican-American protegee, and the city's inspirational but secretive Mayor all struggle for power during an invasion of the city by the world's most murderous drug cartel.

Wayne's off-the-books operations finally catch up to him as Isa's fiancé pursues a lead that could put both Wayne and Isa in jail. Isa has to create a fake asset to cover up for Wayne’s misbehavior. Meanwhile, Bautista threatens Wayne’s life, but mysteriously, and ominously, lets him live. Veronica starts to realize the truth about her marriage. And Lalo gets his hands dirtier than ever before.