Espionage, crime and politics collide in modern day Mexico City. A brilliant but self-destructive CIA officer, his young and ambitious Mexican-American protegee, and the city's inspirational but secretive Mayor all struggle for power during an invasion of the city by the world's most murderous drug cartel.

Wayne, Isa and Pamela undertake a dangerous mission, infiltrating a corrupt banker who could lead them to the Guerrero cartel. Lalo and Isa start to bond while working on an art exhibition, but their past conflicts re-emerge to threaten their friendship. And Bautista’s sicarios conduct a mysterious operation that ends up having terrifying consequences for the city.

Wayne, Isa and Romero work frantically to rescue the hostages. Lalo and his police force do the same, but Lalo has his own agenda. Bautista carries out a mysterious plan involving his sicarios. And Wayne and Isa eventually come a terrible realization about why Bautista invaded the city.

Lalo's left reeling from the events of the last episode. He takes Isa on a trip to his family’s estate outside of the city, which allows Isa to learn one of Lalo’s biggest secrets. Meanwhile, Wayne discovers Bautista’s weakness and uses it to lay a trap for the narco. But Bautista is also laying a trap of his own.

Isa breaks with Wayne over the recent bloodshed and engages in risky behavior, both professional and personally. Wayne visits a figure from his past, and in flashback, we learn the tragic origins of his hatred for Bautista. Bautista takes a physical and spiritual journey into the hills of Guerrero, coming to a decision that will have horrible consequences for Lalo and the entire country of Mexico.

Wayne's off-the-books operations finally catch up to him as Isa's fiancé pursues a lead that could put both Wayne and Isa in jail. Isa has to create a fake asset to cover up for Wayne’s misbehavior. Meanwhile, Bautista threatens Wayne’s life, but mysteriously, and ominously, lets him live. Veronica starts to realize the truth about her marriage. And Lalo gets his hands dirtier than ever before.