After a woman in a troubled marriage, whom Hooker meets in a bar, is fatally stabbed, he notices a similarity with three other cases, and a pattern emerges that all of the women had phoned in to a relationship therapist's call-in radio show before they were murdered. Convinced that the connection to the radio station is the key to the killings, he tries to persuade the show's therapist to help him track down the killer, but she is very reluctant, worrying that the bad publicity will stop callers to her show... During the investigation, Stacy and Corrigan rescue a young baby and it's mother from a brutal attack stirs feelings between them...

When Hooker and the team assist in a large drugs bust, the main dealer escapes, but a videotape is seized that incriminates Hooker for seemingly taking bribes to keep prostitutes out of jail. Stripped of his badge and gun as he awaits being charged with corruption, he travels to Las Vegas and meets up with the prostitute accused of bribing him, in a bid to clear his name and get to the bottom of the drug operation by nailing the mastermind crime lord at it's centre... Meanwhile, Corrigan asks Romano to use his trainee lawyer skills to help a pregnant woman caught up at the scene of the bust who is an illegal immigrant...

An attractive woman named Teri, whom Hooker meets when giving a speeding ticket, finds that her friend has been robbed and raped, and herself is attacked when she unwittingly stumbles onto the scene, until Hooker comes to the rescue. She aids him as they try to identify the violent gang behind the attacks, and in their together, they quickly fall in love, but things take a nasty turn when the gang track Teri down and badly attack and rape her. The result of the attack takes its toll on her and Hooker's relationship, and causes Corrigan, Stacy and Romano to become concerned that Hooker's fierce pursuit of the gang is being clouded by personal feelings and the want for revenge...

Hooker's investigation into a series of gristly murders by a pair of religious crazies is accompanied by Sergeant Leigh Stockwell, a close, old friend, whom is somewhat his protégé. But Stacy becomes suspicious that Leigh is using cocaine, an addiction which not only jeopardises the case and Leigh's job, but also Hooker's life...

After an armed box office heist where the robbers escape on motorcycles leaves Hooker and Romano's patrol car destroyed by a bomb and a young man dead, Hooker and the team are on the look out for an infamous criminal named Willie Donovan, whom Corrigan has a grudge against after the collapse of a previous investigation. But a shoot-out with Donovan which leaves Donovan dead, a gun from the robbery room of Corrigan's previous Police department, and an exaggerated report of Police brutality from a informant all mount up to Corrigan being assigned to desk duty while he is investigated. Hooker intends to prove Corrigan's innocence, while putting a stop to the series of robberies...

Hooker goes to Chicago on a supposedly simple three hour extradition trip, to bring back a felon wanted for fencing stolen items, but ends up being paired with fast-talking, wise-cracking Detective Sidney P. Stover, who is planning to use the fencer Hooker is due to take back to arrange a bust on a dangerous drug supplier's operation...