The U.S.S. Enterprise encounters a contagion that ravages the ship. One by one, the entire crew is incapacitated except for Number One, Una Chin-Riley, who must now confront a secret she’s been hiding as she races to find a cure.

A threat to an idyllic planet reunites Captain Pike with the lost love of his life. To protect her and a scientific holy child from a conspiracy, Pike offers his help and is forced to face unresolved feelings of his past.

An accident while investigating a time portal sends Ensign Brad Boimler through time from the twenty-fourth century, and Captain Pike and his crew must get him back where he belongs before he can somehow alter the timeline.

An accident with an experimental quantum probability field causes everyone on the U.S.S. Enterprise to break uncontrollably into song, but the real danger is that the field is expanding and beginning to impact other ships—allies and enemies alike.

Pike and M'Benga enter disputed Klingon space to find a cure for Batel, as M'Benga's past resurfaces on a planet swarming with deadly creatures.