A returning patient wreaks havoc for Jac, and Sacha fears for his daughter while Jodie is on the loose.

The hospital is locked down with a gunman on the loose. Trapped in theatre, Cameron needs Nicky's help if he is not to be exposed as being way out of his depth.

Assisting in Eli’s experimental stent trial proves to be the hardest professional challenge of Chloe’s life. Can she overcome her fears? Donna’s teenage daughter Mia arrives drunk on the Holby doorstep after a party with Jeni’s dodgy clients, and as Carole’s dementia worsens, Jeong helps Dominic take her on an imaginary trip to the seaside.

Hanssen trawls hospital CCTV for a potential threat. As Carole’s dementia worsens, taking part in the experimental stent trial becomes increasingly risky. Aleysa, another of Jeni’s girls, is admitted with a suspicious cut on her arm.

Nicky must find the strength to be a mother to Juliet or give away her baby for good. As the hospital is forced to lock down, Hanssen has to help deliver Billie's baby. As AAU handles the Darwin overflow, Ange notices Madge behaving suspiciously.

Kylie believes Madge is the victim of domestic abuse, Dom receives a lucrative offer from a private hospital, and Russ needs to proritise being a father to Billie.