Jack is now engaged to Jayne but overreacts when new nurse Tina Seabrook makes an unfortunate comment about a man who deliberately fell off a ladder to get into hospital. Josh and Liz try to get Ian and Esme, a couple who are having a baby to the hospital, but end up having to deliver the baby in the back of an ambulance. Young black couple Jason and Lou are arguing about her desire to join the police, who Jason sees as institutionally racist. After they part ways, Jason sees someone park a van in the car park at a shopping centre. A bomb in the van goes off, causing many casualties. An elderly man removes glass imbedded in his wife's stomach and she dies of internal bleeding. Lou seems to have minor injuries but in hospital a scan shows she has a bleed on the brain, which leaves her in a coma. Ian has been left trapped in rubble and when a second bomb is discovered Baz and Josh amputate his foot to get him out.

An underage prostitute, Lucy, is lured to a garage by a client where she is beaten up by a group of men and dumped outside the hospital. Jack warns George about getting too involved in the case. Lucy's friend Julie turns up and it transpires she set up the beating because Lucy was planning on quitting the game. Lucy initially leaves with Julie but later returns to see George. Liz argues with her husband John, who thinks she is not spending enough time at home. A young woman brings in her older neighbour; they are involved in a dispute over a fence and the older woman tripped over. Sam manages to get them talking. A young man with a history of mental health issues pushes his mother (Brigit Forsyth) down the stairs. Richard and Kate convince her to have him sent to a psychiatric hospital.

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A little girl and three professors have a Christmas they would rather forget, while the staff of A&E let their hair down for a party to end all parties.

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A football fiasco results in a medical disaster for the local team's star player, while consultant Max receives devastating news about the A&E&'s future.

Charlie and Max are concerned by the overwhelming number of patients' complaints, while the rest of the staff cope with a tourist returning from Thailand with stomach pains.

Sean faces a tough time as an injured fireman and his pregnant girlfriend land him with a moral dilemma, while Penny helps Josh to cope with his gambling addiction.

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The A&E staff have to deal with the aftermath of tear-gassing and gang violence. George contemplates applying for a job at Broadway General.

Sean's future looks bleak as the hearing into Eugene Rafferty's death begins. George gets a job offer, and Max feels the need for a swift vodka.

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Sam finds himself in a dangerous situation, while everyone waits anxiously for news about Josh and George.