Carolina, who is suffering from a mysterious illness, is admitted to the ward, triggering a series of conflicts between Andrea and Agnese that they will have to overcome for their daughter's sake. Meanwhile, a flashy influencer attracts the young trainees' attention and Alba cannot disguise her jealousy towards Riccardo.

Again with his white coat, Doc faces his first day as head physician. He has new responsibilities to manage without neglecting patients, despite pressure from the Administrative Director who threatens to close the department. Fortunately, Doc can count on his team, although Julia has not set aside the idea of leaving and Richard is challenged by the new residents.

After a new memory, Andrea finds it hard to believe what his memory seems to be suggesting to him, and he asks Enrico to discontinue treatment. Even on the ward, the situation is far from quiet. In addition to Rita, a young girl who refuses chemotherapy, Andrea and his team have to deal with the case of a patient they know all too well.

The fear of discovering the secret about his past is too strong for Doc. However, this denial of the truth drives him away from the ward, much to the surprise of Giulia, who has to take care of a patient who, just like Andrea, seems to be hiding something. Meanwhile, Enrico must deal with Barbara's assaults, which may be hiding more than just infatuation.

Doc enters a competition with an AI: if he does not want to be replaced by a machine, he must find the correct diagnosis for a patient before the computer. Martina, on the other hand, is given a case that forces her to come to terms with her conscience, while Agnese is confronted with a terrible decision to protect one of Andrea's secrets.

A violent earthquake sows panic at the Ambrosiano Hospital. Lin is afraid for her family; Ric decides on Laura's proposal; Federico has to perform a surgery for which he does not feel ready; Martina has an encounter that threatens to bring up her secret; Giulia, on the other hand, has to manage the ward because Doc is stuck in an elevator and has to save a pregnant patient.

In the ward, the moment of truth has arrived. As Federico faces his last day at Ambrosiano Hospital and Martina makes a decision that leaves the rest of the team stunned, Doc must come to terms with the truth Agnese has told him. He is convinced that it can't get any worse - until the man responsible for it all, his worst enemy, is admitted.