Andrea returns to the ward as an assistant to the trainees, who were terrified of him just a few weeks earlier and find it hard to get used to the unexpected role reversal. While he tries to win back his ex-wife, his collaboration with Giulia on the case of a young manager proves to be challenging and full of surprises.

The arrival of a patient who is particularly important to Giulia intensifies the competition between the interns and Andrea has an opportunity to really get to know them. Meanwhile, he involves the ward in the search for his email account password, which could help him reconstruct a key part of his past, but which someone wants to hide from him at all costs.

A special episode set ten years earlier. Andrea, an enthusiastic doctor who is still together with his family, has an opportunity to make a career jump for the first time. But it is a struggle to hold everything together: suddenly finding himself involved in a rivalry with his colleague Marco, he risks losing sight of who he really is.

The arrival of Elisa's older sister in the hospital, a likeable, charming actress, inexplicably makes the young trainee even more surly and bad-tempered. Andrea continues to delve into the years that amnesia has wiped out, while Agnese cannot mask her jealousy over the growing rapport between Giulia and Andrea.

Lorenzo has issues again with his ex-girlfriend Chiara, who is then hospitalized after overdosing. Marco and his wife feel increasingly threatened by the research that Andrea is carrying out on Satonal, the experimental drug that appears to have caused several deaths. Meanwhile, Gabriel has to explain to his community that he intends to settle in Italy.

In this special episode, while the investigation conducted by Caruso comes to life and the secrets of the pandemic begin to emerge, Andrea faces a difficult choice: to get back the primary he must take tests, but if he fails, he will never be able to be a doctor again.

All the secrets come to light in this special episode, a tribute to the medical heroes of the pandemic.

Agnese is surprised to find Manuel's mother hospitalized, the child she has in foster care with Davide, and with whom things do not seem to go too well. Agnese will have to question everything she thinks she knows, just when Andrea seems to want to be closer to her than ever.

When he is one step away from regaining the primary, Doc is forced to a painful confession in front of the whole department.

The news of Doc's memory upsets the ward's balance: Agnese fears that recovering his memory will destabilize Andrea's new life, while Damiano is worried about the effect this might have on Giulia. Doc, on the other hand, is increasingly elated, although it is not easy to wedge the therapy prescribed for him by Enrico between the thousands of commitments as head physician.

Doc sees some of the certainties he had about his past collapsing and, to shed light on what happened, he also drags Giulia into his search, who is challenged by the idea that her relationship with Andrea was based on a lie. Angelo, a patient whose condition forces Martina to prove herself, has problems with his past, too.

Agnese's words have created a rift with Andrea, who must also come to terms with being away from Giulia, who is in Rome for research. Meanwhile, Teresa must work wonders to find a place for Diana's daughter, admitted despite her mother's doubts. Elisabetta is also admitted to the ward after a few days of illness, maybe an indication of a more serious problem.

Giulia must make a decision about her personal life that will also affect her career. While Martina faces the most difficult exam of her life, Ric takes on a case that will force him to come to terms with Alba's ghost. Lin and Federico, on the other hand, get back to work on the database, but they risk bringing Doc closer to the truth that Agnese has been hiding from him.

Andrea is forced to come to terms with Agnese's illness, but unexpected news from America reawaken his hopes. At the hospital, however, the new head physician is challenged by a case that will force someone to make a terrible compromise. Meanwhile, Lorenzo is entrusted with a patient who has arrived from a nursing home and has been prescribed an overdose of medication.