Goede tijden, slechte tijden, also known as GTST, is the longest-running Dutch soap opera, revolving around the lives of the families Alberts, Sanders, De Jong, Van Houten and Bouwhuis. It all takes place in the fictional town of Meerdijk.

Gooische Vrouwen is a Dutch comedy-drama series, created by Linda de Mol for her brother John de Mol's TV network Tien in 2005. However, after the show's second season, Tien went bankrupt and Gooische Vrouwen was transferred to RTL4, where it ran for three more seasons until its finale in 2009. After its 42-episode run the show was followed by a theatrically released feature film in 2011. The show chronicles the everyday lives of four female friends living in het Gooi.

Gooische Vrouwen has since been sold to Germany, Belgium, France and Serbia.

Dit was het nieuws is a Dutch television program of RTL4, wherein two teams give a satirical account of the previous week's news. The program has the form of a game show in which two teams, each with a team leader and weekly guest, compete against each other. The scoring is not serious; after the first round, for instance, the score is always 4-4.

A reality survival program in which BN'ers do battle with each other and the elements.

Eigen Huis & Tuin is a Dutch television program about do it yourself related topics. It started in 1990 and is broadcast on Saturday evenings on RTL 4. It has about half a million viewers weekly.

Dutch reality singing competition where four coaches, themselves popular performing artists, train the talents in their group and occasionally perform with them. Talents are selected in blind auditions, where the coaches cannot see, but only hear the auditioner.

Baantjer is a Dutch television programme which was broadcast by RTL 4 from 6 October 1995 until 1 December 2006 for a total of 123 episodes in 12 seasons. It stars Piet Römer as Jurriaan 'Jurre' de Cock, a police detective, and Victor Reinier as Dick Vledder, his helper. The series is based on the novels of writer A. C. Baantjer.

In 1999, RTL 4 broadcast the television film Baantjer, de film: De Cock en de wraak zonder einde because of the tenth anniversary of the network.

Documentary show in which presentor Beau van Erven Dorens visits facilities in The Netherlands that you normally cannot enter such as a hospice, a preventitive custody facility and a burn center. Beau gets a look into the life of the people and employees by staying there for five days and experiencing how it is to work or live there. He also spends the night there, often locked in a room for his own safety.

Peter and Eva, a nice young couple expecting their first child, buy a house in a suburban village. Before they get to move into their new home, they lose their baby girl. Eva has a hard time coping with her loss. Peter has mixed feelings. The baby wasn’t his to begin with.He’s infertile and hopes the chapter of having children has now come to an end. Then they meet their new neighbors Rebecca and Steve, a carefree outgoing couple, that helps them forget their pain. But are they really who they say they are?