Upon taking her vows to become a nun, Sister Sarah is abused, brainwashed and also drugged into submission by the corrupt clergy. On the verge of her own death from a lethal dose of drugs, Sister Sarah receives a message from God telling her to take vengeance on all those who did wrong to her. Armed with God's will and an arsenal of big guns, she dispenses Judgment Day on her former tormentors. When the church hires the merciless motorcycle gang "Los Muertos" to track down and to kill her they soon realize that this sister is one bad mother.

Two slave brothers, one black, one an albino, discover a treasure map which is taken from them by their foreman. They take it back but are pursued by the foreman. Originally, the foreman seeks the aid of two bounty hunters who pursue the protagonists throughout the film. At the end, both the foreman and the bounty hunters catch up with the two escaped slaves, and the foreman has a change of heart, helping to kill the bounty hunters.